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KMID : 0352819860020010053
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Kosin Medical Journal
1986 Volume.2 No. 1 p.53 ~ p.61
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STUDIES OF Ginseng SAPONIN FRACTIONS ON CHOLESTEROL ABSORPTION AND BLOOD SERUM LIPIDS IN RATS
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Lee, Song Jae
Jeong, In Cheol/Cho, Moo Youn
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Abstract
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It was attempted in this present study to observe the effect of ginseng saponin fractions, one of the active components of ginseng, on cholesterol absorption using the radioactive material and the blood serum lipids in orally long-term administeration of ginseng saponin fraction to rats.
1) The purified ginseng total saponin was identified with High Performance Liquid Chromatography.
2) It was demonstrated that the absorption peak pattern o; blood serum and hepatic lipid on time course after the 4-"C-cholesterol feeding was similar between two groups. However, the radioactivity value of ginseng saponin administered rats was much higher than that of control rats.
3 ) In protopanaxdiol saponin fed rats, the absorption peak pattern and the radioactivity value of blood serum and hepatic lipid was similar between two groups.
4) The absorption peak pattern of blood serum lipid and hepatic lipid in protopanaxtriol saponin fed rats showed that the highest peak of radioactivity appeared earlier than control, furthermore the radioactivity value of the test group was much higher than that of control group.
These results suggest that the above stimulatory effect of ginseng total saponin on cholesterol absorption might be due to the protopanaxtriol saponin.
5 ) The radioactivity value of the prosapogenin administered rats was also much higher than control group.
These results suggest that ginseng saponin, during digestion, would greatly be favorable for the formation of micellar structure of non polar lipids (such as triglycerides and cholesterol) with bile salts, phospholipids and other polar lipids so that fatty materials might be absorbed effectively from small intestine.
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